Mechanisms Involved in the Antinociceptive Effects of 7-Hydroxycoumarin

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Mechanisms involved in the antinociceptive effects of 7-hydroxycoumarin.

7-Hydroxycoumarin (umbelliferone, 1), the main metabolite of coumarin, has been reported to produce potent antinociceptive effects in animal models of pain. However, the biochemical events involved in antinociception mediated by 1 are currently not well understood. In the present study, the mechanisms by which 1 exerts its pharmacological actions were investigated. Acute pretreatment of mice wi...

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ژورنال

عنوان ژورنال: Journal of Natural Products

سال: 2011

ISSN: 0163-3864,1520-6025

DOI: 10.1021/np100621c